In the laboratories of the Fine Chemistry Pilot Plant, organic synthesis projects are carried out that include obtaining compounds at various scales (from mg to Kg), integrating procedures, "green" technologies and ICH guidelines into the synthetic routes. The most representative activities carried out in the last 25 years are detailed.

    • Synthesis and development of new drugs and molecules with high added value.
    • Improved methods for the synthesis of generic drugs.
    • Design and optimization of new synthesis routes.
    • Synthesis of pilot batches of drugs in development, for preclinical use.
    • Synthesis of non-commercial organic products and intermediates, up to kilolab scale.
    • Optimization of seedings.
    • Scaling of processes and products.
    • Synthesis of synthesis impurities, nitrosamines, degradation products and metabolites of APIs and drugs.
    • Synthesis of standards.
    • Synthesis of polymeric materials.
    • Peptide synthesis.
    • Synthesis of organometallic compounds.
    • Total synthesis of bioactive natural products.
    • Integration of "green" technologies in industrial chemical production.
    • Preparation of Drug Master File.